糖尿病患者免疫功能变化及其与腺苷脱氨酶水平的相关性

摘要

目的 探测糖尿病患者细胞免疫功能的变化及其与腺苷脱氨酶的关系.方法 分析检测65例1型糖尿病患者、82例2型糖尿病患者以及80例正常对照组的空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)、T细胞亚群(CD3、CD4、CD4/CD8)、WBC以及腺苷脱氨酶(ADA)水平.结果 DM1组与DM2组FPG、2hPG和HbA1c差异无统计学意义(P值均＞0.05).DM1和DM2组的CD3、CD4亚群均比对照组显著降低(P＜0.05),DM2组的WBC和ADA水平与对照组比较有统计学意义(P＜0.05),DM2组ADA与CD3、CD4和CD4/CD8成正相关.结论 糖尿病患者机体均存在明显的免疫功能紊乱,2型糖尿病患者血清ADA的动态观察对患者早期肾损伤诊断有重要参考价值.%Objective To investigate the cellular immunity function change of patients with diabetes and its relationships with adenosine deaminas. Methods FPG, 2hPG, HbAlc, T lymphocyte subsets (including CD,, CD,and CD4/CD0,WBC and ADA levels were measured in 63 patients with Type 1 diabetes, 82 patients with Type 2 diabetes and 30 controls. Results There were no significant differences in FPG, 2hPG and HbAlc between DM1 group and DM2 group. The percentage of CD8 T cells, CD4/CD8 T cells was increased while CD, T cells, CD4 T cells were decreased in those with DM1 and DM2. There were significant differences between all of the above changes and those in the control group (P<0.05). levels of WBC and ADA were significantly higher in DM, than those in controls (P<0.05). In group DM2, ADA levels were positively correlated with CD,, CD4 and CD4/CDs (P<0.05). Conclusion There are evident cellular immunity functional disorder in diabetic patients. Continuous measurement of serum ADA level in type 2 diabetes may be helpful for early detection of diabetic nephropathy.