目的 探讨ERCC-1和COX-2在非小细胞肺癌中的表达水平,分析两者与非小细胞肺癌患者预后的相关性.方法 采用免疫组织化学法检测96例非小细胞肺癌组织中的ERCC-1和COX-2表达水平,分析两者与临床病理参数间的相关性.结果 ERCC-1与NSCLC的病理相关性分析显示,病理类型、TNM分期及预后与ERCC-1的阳性表达密切相关(P＜0.05).COX-2与NSCLC的病理相关性分析显示,病理类型、分化程度与COX-2的阳性表达密切相关(P＜0.05).ERCC-1蛋白表达与COX-2蛋白表达的相关性分析显示ERCC-1和COX-2蛋白表达不相关.结论 COX-2蛋白及ERCC-I在NSCLC中均有不同程度的表达,检测COX-2及ERCC-1表达对NSCLC预后的判断具有一定价值.%Objective To investigate the expression of ERCC-1 and COX-2 in non-small cell lung cancer (NSCLC), and to analyze their correlation with the prognosis of NSCLC. Methods Immunohistochemishy methods were used to detect the expression levels of ERCC-1 and COX-2 in 96 patients of NSCLC. The correlation between the expression of the two proteins and the clinical pathology were analyzed. Results The pathologic correlation analysis between ERCC-1 and NSCLC revealed that the pathological types, TNM staging and the prognosis were related closely with the positive expression of ERCC-1 protein (P<0.05). The pathologic correlation analysis between COX-2 and NSCLC showed that the pathological types and differentiation degree were related closely with the positive expression of COX-2 protein, P<0.05. No correlation was found between the expression of ERCC-1 protein and COX-2 protein. Conclusion COX-2 and ERCC-1 proteins have different degree of expression in NSCLC. Detecting the expression levels of COX-2 and ERCC-1 is of certain value in the prognosis of NSCLC.
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