PHY906研究模式与中药作为癌症辅助治疗剂的现代研究

摘要

Scientists at Yale University have explored PHY906,which is derived from an ancient Chinese herbal formulation Huang-Qin-Tang,as a standardized botanical drug.Based on traditional claims in Chinese medicine documents,PHY906 was found to enhance the benefits and simultaneously reduce the side effects of the combined chemotherapy agents for cancer.The scientists have undertaken systematic studies,including preclinical studies,mechanisms of action,and clinical studies,for PHY906.A comprehensive platform,Phytomics QC that integrates chemical and biological fingerprints together with a novel biostatistical methodology has been developed to assess the quality of different batches of PHY906.The research approaches of PHY906 involved quality control,evidence-based medicines,systems biology and "omics" methods.Chinese traditional herbal medicines as adjuvant treatment play important roles during chemotherapy for cancer.We should utilize modern multidisciplinary technologies to elucidate the effectiveness and safety and illustrate the likely mechanistic basis of Chinese traditional herbs.%Yale大学科学家将传统中药黄芩汤开发成现代植物药制剂PHY906,基于功效主治发现其具有增强化疗药物的治疗效果、降低化疗毒性的作用.学者们围绕这一作用,开展了系统的临床前研究、作用机制研究和临床研究,创立了Phytomics QC质量控制平台.PHY906研究中体现的质量控制理念、询证医学及系统生物学的方法论、良好研究规范值得我们借鉴和学习.中药作为癌症辅助治疗剂潜力巨大,我们需要循序渐进的开展工作,用现代科学和技术证实其有效性和安全性,阐明内在作用机制.