目的 分析我院细菌性角膜炎致病菌属的分布及其耐药性.方法 选取我院980 份细菌性角膜炎 患者标本进行细菌培养,并进行药敏试验,观察其致病菌属的分布以及其耐药性.结果 细菌培养阳性者332 株,阳性率为33.9%;G+球菌152 株(45.8%)、G-球菌8 株(2.4%)、G+杆菌36 株(10.8%)、G-杆菌136 株(41.0%).表皮 葡萄球菌比例最高,占27.1%,其次为铜绿假单胞菌,占19.6%.革兰氏阳性菌中对万古霉素、利奈唑胺、莫西沙星 等高度敏感.革兰氏阴性菌对阿米卡星、亚胺培南、莫西沙星等敏感,而氨苄西林、苯唑西林耐药率高.结论 假 单孢菌属及葡萄球菌属是细菌性角膜炎最常见菌属,其耐药性广泛存在,应根据药敏试验结果正确选择抗菌药物.%Objective To analyze the genus distribution and drug resistance of bacterial keratitis pathogenic bacteria. Methods Nine hundred and eighty specimens of bacterial keratitis patients were cultured for drug sensitive test. The bacterial distribution and drug resistance were observed. Results Bacterial culture was positive in 332 strains, with the positive rate of 33.9%, including 152 (45.8%) strains of G1 aureus, 8 strains of G- aureus (2.4%), 36 strains of G+ coli (10.8%), 136 (41%) strains of G-coli. Staphylococcus epidermidu occupied the highest proportion, accounting for 27.1%, followed by Pseudomonas aeruginosa (19.6%). Gram positive bacteria were highly sensitive to vancomycin, linezolid, moxifloxacin. Gram negative bacteria were sensitive to imipenem, Amikacin, moxifloxacin, while resistant to ampicillin and oxacillin. Conclusion Pseudomonas and Staphylococcus aureus is the most common bacterial keratitis fungus, with wide resistance. The application of antibacterial drugs should be based on the results of drug sensitivity tests.
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