非小细胞肺癌患者氨基酸肠外营养辅助治疗的疗效及其对患者血清炎症因子的影响

摘要

目的 探讨化疗配合氨基酸肠外营养治疗非小细胞肺癌(NSCLC)的疗效及其对患者血清炎性因子的影响.方法 将我院2009 年1 月至2011 年12 月肿瘤科收治的120 例NSCLC患者根据所采用的治疗方法不同分为观察组和对照组,每组60 例,其中观察组采用化疗配合氨基酸肠外营养治疗,对照组单纯采用化疗药物治疗,两组患者治疗两个疗程后,比较其总有效率、生存时间、生活质量、毒性反应及血清炎性因子.结果 观察组治疗后有效率为75.00%,6 个月~1 年与1 年以上生存率分别为65.00%与51.67%,生活质量改善有效率为80.00%,Ⅲ~Ⅳ°骨髓抑制与消化道反应发生率分别为13.33%、53.33%,CRP 值≤12.5 μg/ml 百分比为88.33%,TNF-α含量(92.54±9.18) pg/ml;对照组治疗后有效率为60.00%,6 个月~1 年与1 年以上生存率分别为53.33%与41.67%,生活质量改善有效率为60.00%,Ⅲ~Ⅳ°骨髓抑制与消化道反应发生率分别为20.00%、71.67%,CRP 值≤12.5 μg/ml 百分比为76.67%,TNF-α含量(82.05±10.17) pg/ml,两组以上各项指标比较差异均具有统计学意义(P<0.05).结论 化疗配合氨基酸肠外营养治疗NSCLC比单纯应用化疗的治疗有效率高,患者生存时间长,生活质量好,并且毒性反应程度较低,有助于降低患者的炎性状态,提高机体的免疫功能,值得临床推广应用.%Objective To investigate the efficacy of chemotherapy combined with amino acid parenteral nutrition for treating non-small cell lung cancer (NSCLC) and its effect on serum inflammatory factors. Methods One hundred and twenty patients with NSCLC were analyzed, who admitted from January 2009 to December 2011. The patients were divided into observation group and the control group depending on the method used, with 60 cases in each group. The observation group was treated with chemotherapy combined with amino acid parenteral nutrition, while the control group was treated with chemotherapy for treatment. The two groups were treated for two courses. The total efficiency, survival time, quality of life, toxicity, and serum inflammatory factors were compared between the two groups. Results In the observation group and the control group, the treatment efficiency was 75.00%, 60.00%, the survival rates of 6 months to 1 year and more than 1 year were 65.00% and 51.67%, 53.33% and 41.67%, the life quality improving effective rates were 80.00% and 60.00%, Ⅲ~Ⅳ°bone marrow suppression and gastrointestinal reactions occurred rates were 13.33% and 53.33%, 20.00% and 71.67%, CRP valued 12.5 |ig/ml the percentages were 88.33%, 76.67%, and the content of TNF-a was (92.54±9.18) pg/ml, (82.05±10.17) pg/ml, respectively. The difference was statistically significant between the two groups (P<0.05). Conclusion Chemotherapy combined with amino acid parenteral nutrition is more efficient to treat NSCLC, which can reduce the inflammatory state of patients and improve the body's immune function, with longer patient survival, better quality of life, and lower level of toxicity,