意外抗体筛查检出抗“Mur”抗体的临床意义

摘要

Objective To investigate the clinical significance of unexpected antibody screening with detec-tion of anti-Mur antibody by preparation of Mur antigen, for the purpose of selecting the appropriate blood for clini-cal transfusion, preventing the transfusion reaction and assuring the safety and efficiency in clinical transfusion. Methods First, with panel cells containing Mur antigen, we screened out anti-Mur antibody. Then, we prepared the Mur antigen as new sieve cells used in unexpected blood screening before transfusion. Results Totally 68 (0.83%) samples were positive among 8 200 samples by antibody screen test. Of the 68 cases, 33 cases had a history of repeat-ed transfusion, 26 cases had a history of pregnancy and 38 cases had difficulty of blood matching because of the unex-pected antibody. Conclusion Screening of unexpected antibody (anti-Mur) could effectively improve the safety of clini-cal transfusion, which is of great clinical value.%目的：通过对“Mur”抗原的制备研究，探讨意外抗体筛查检出抗“Mur”抗体的临床意义，为临床选择合适的血液，预防输血反应，确保有效输血及输血安全。方法首先用含Mur抗原谱细胞筛查出抗“Mur”抗体，然后用该抗“Mur”抗体制备“Mur”抗原作为4号筛查细胞，用于输血前的意外抗体筛查。结果8200例抗体筛查中抗“Mur”抗体阳性68例，阳性率为0.83%。该68例患者中，33例有反复输血史，26例有妊娠史，由于产生意外抗体而引起疑难配血者38例。结论意外抗体筛查检出抗“Mur”抗体能有效提高临床输血安全，具有重要的临床价值。