Objective To investigate the expression and clinical significance of AEG-1 in bladder cancer tis-sues. Methods Immunohistochemistry (IHC) was used to detect the expression of AEG-1 in 224 cases of bladder cancer tissues and 56 cases of normal bladder tissues. The relationships between AEG-1 expression and clinical patho-logical parameters were also analyzed. Results The expression of AEG-1 was significantly higher in bladder cancer tissues than in normal bladder tissues (P<0.01), in male patients than female patients (P<0.05), in higher levels of blad-der cancer than lower levels of bladder cancer (P<0.01), in bladder cancer tissues of stageⅢandⅣthan bladder can-cer tissues of stageⅠandⅡ(P<0.01), in patients with lymphatic metastasis than those without lymphatic metastasis (P<0.001), in patients with tumor diameter≥3 cm than those with tumor diameter<3 cm (P<0.01), as well as in pa-tients with recurrence than those without recurrence (P<0.001). Conclusion Overexpression of AEG-1 is closely cor-related with tumorigenesis and development of bladder cancer.%目的 探讨星形细胞上调基因-1 (AEG-1)在膀胱癌组织中的表达及其临床意义.方法 采用免疫组织化学法检测224例膀胱癌组织及56例正常膀胱组织中AEG-1表达的差异及其与相关临床病理参数间的关系.结果 AEG-1在膀胱癌组织中的表达显著高于正常膀胱组织(P<0.01);男性膀胱癌患者AEG-1的表达明显高于女性膀胱癌患者(P<0.05);膀胱癌高级别组中的表达显著高于低级别组(P<0.01);膀胱癌Ⅲ、Ⅳ期者显著高于Ⅰ、Ⅱ期者(P<0.01);伴有淋巴结转移者AEG-1的表达显著高于无淋巴结转移者(P<0.01);肿瘤直径≥3 cm组AEG-1的表达显著高于肿瘤直径<3 cm组(P<0.01).膀胱癌复发组AEG-1的表达显著高于无复发组(P<0.01).结论 AEG-1的高表达与膀胱癌的发生与演变密切相关.
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