目的：探讨脑钠肽(BNP)检测预测心绞痛复发的临床价值。方法选取我科2011年1月至2013年1月收治的82例稳定性心绞痛患者，所有患者均随访至2014年8月，以心绞痛再发为随访终点，按照是否再发分为未再发组72例和再发组10例。比较两组患者治疗前后的BNP水平、成功治疗后的基本特点，采用受试者工作特征(ROC)曲线计算BNP成功治疗后预测心绞痛的截断值，同时预测心绞痛再发的敏感性和特异性。结果未再发组成功治疗后的BNP水平显著低于治疗前与再发组治疗后，再发组成功治疗后的BNP水平显著高于治疗前(P<0.01)。未再发组的收缩压(SBP)、舒张压(DBP)、总甘油三酯(TG)和总胆固醇(TC)水平水平明显低于再发组(P<0.05)。BNP在成功治疗后缓解期的截断值为58.20 pg/ml，其ROC曲线的敏感性为71.09%，特异性为96.97%。结论稳定性心绞痛患者在其治疗前后测定其BNP水平，对于预测心绞痛再发有一定临床价值。%Objective To analyze the clinical value of brain natriuretic peptide (BNP) detection in predicting recurrence of angina. Methods Eighty-two patients of unstable angina in our department from January 2011 to Janu-ary 2013 were enrolled in the study. The patients were followed up to August 2014, with angina recurrence as the end of follow-up. According to the recurrence status, the patients were divided into non-recurrence group (n=72) and recur-rence group (n=10). BNP levels before and after treatment and the basic characteristics of successful treatment were compared in two groups of patients. Receiver operating characteristic (ROC) curve was used to calculate BNP cutoff value to predict angina pectoris after successful treatment and predict the sensitivity and specificity. Results BNP levels in non-recurrence group after treatment were significantly lower than those before treatment, and the levels was also significantly lower than those in recurrence group (P<0.01). BNP levels in recurrence group after treatment were significantly higher than those before treatment (P<0.01). Systolic blood pressure (SBP), diastolic blood pres-sure (DBP), total triglyceride (TG) and total cholesterol (TC) levels in the non-recurrence group were significantly lower than those in the recurrence group, P<0.05. BNP cut-off value in remission after successful treatment was 58.20 pg/ml, and the sensitivity,specificity were 71.09%, 96.97%in the ROC curve. Conclusion For patients with stable angina, BNP levels detection before and after treatment shows certain clinical value for the prediction of re-current angina.
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