Objective To analyze the correlation of peptic ulcer with ABO blood type, Helicobacter pylori in-fection, and Lewis phenotype distribution. Methods Seventy-five patients with peptic ulcer were selected as the ob-servation group and 75 health adults were enrolled as the control group (with hospitalized time limited from January 2010 to December 2013). The differences of subjects' pylori infection, ABO blood type and Lewis phenotype distribu-tion between the two groups were analyzed. Results ①There were 26 Le (a+b+) cases in the observation group (ac-counting for 34.67%), with only 8 in the control group (10.67%), and the difference was statistically significant (P<0.01); ② In the observation group, the Helicobacter pylori infection rate between patients with different ABO blood type (type A 57.14%, type B 50%, type O 52.78%, type AB 57.14%) showed no statistically significant difference (P>0.05);the infection rate of Le (a-b+) patients was 71.79%, which was significantly higher than that of other Lewis phe-notype, and the difference was statistically significant (P<0.01). Conclusion There is a certain correlation between peptic ulcer, Helicobacter pylori infection and Lewis phenotype distribution. People with Le (a+b+) Lewis phenotype may be at higher risk of peptic ulcer, and people with Le (a-b+) may be at higher risk of Helicobacter pylori infection.%目的：探讨消化性溃疡与ABO血型、幽门螺杆菌感染及Lewis表型分布的关系。方法选取我院2010年1月至2013年12月收治的75例消化性溃疡患者作为观察组，75例健康成年人作为对照组，分析两组研究对象的门螺杆菌感染、ABO血型以及Lewis表型分布差异。结果①观察组患者中Le(a+b+)患者共26例，占34.67%；对照察组患者中Le(a+b+)患者共8例，占10.67%，两者比较差异具有显著统计学意义(P<0.01)；②观察组患者中不同ABO血型中幽门螺杆菌的感染率(A型57.14%，B型50.00%，O型52.78%，AB型57.14%)之间比较差异均无统计学意义(P>0.05)；观察组患者中Lewis表型为Le(a-b+)的患者感染率为71.79%，明显高于其他Lewis表型，差异具有显著统计学意义(P<0.01)。结论消化性溃疡与幽门螺杆菌感染以及Lewis表型分布均有一定的关系，Lewis表型为Le(a+b+)的人群消化性溃疡发病风险较大，Lewis表型为Le(a-b+)可能是门螺杆菌感染的高危因素。
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