Objective To observe the curative effect of silver crumbs capsule in treating chronic eczema and its influences on serum interleukin (IL)-4, IL-18 and interferon-γ(IFN-γ). Methods Ninety-eight patients in the De-partment of Dermatology in our hospital from May 2012 to November 2014 were divided into control group and treat-ment group according to a random number method, with 49 patients in each group. Patients in the control group were treated with cetirizine hydrochloride tablets (10 mg/time and qd), and patients in the treatment group was given silver crumbs capsule orally (four capsules/time, bid) based on the control group. The treatment courses were 4 weeks. Main symptoms, signs, change in levels of serum IL-4, IL-18 and IFN-γ, as well as and curative effect were compared be-tween the two groups before and after treatment. Results Before treatment, scores of pimples, erythema, infiltration/hy-pertrophy and moss showed no statistically significant difference between the two both groups (P>0.05). After treatment, scores of pimples, erythema, infiltration/hypertrophy and moss in treatment group were significantly lower than those in the control group (P<0.05). The total effective rate in the treatment group was 93.88%, which was significantly higher than that in the control group of 77.55%(P<0.05). Before treatment, serum levels of IL-4, IL-18 and IFN-γhad no statistically significant difference (P>0.05). After treatment, serum levels of IFN-γand IL-18 in treatment group were significantly lower than those in the control group, while IL-4 in treatment group was significantly higher (P<0.05). Conclusion On the basis of the Western medicine therapy, silver crumbs capsule, in treating chronic eczema with syn-drome of excessive dampness-heat, could significantly improve patients' symptoms, signs and the clinical curative effect. The mechanism may be involving increasing level of IL-4 and decreasing levels of IFN-γ, IL-18.%目的 观察银屑胶囊对慢性湿疹的临床疗效及其对患者血清白介素(IL)-4、IL-18和γ干扰素(IFN-γ)水平的影响.方法 选择我院2012年5月至2014年11月间皮肤科收治且符合纳入标准的患者98例,均为慢性湿疹患者.按数字表法随机分为治疗组和对照组各49例.对照组给予盐酸西替利嗪片治疗,10 mg/次,1次/d;治疗组在对照组治疗基础上给予银屑胶囊口服,4粒/次,2次/d;两组患者疗程均4周.比较两组患者治疗前后主要症状、体征、血清IL-4、IL-18和IFN-γ水平的变化以及治疗效果.结果 治疗前,两组患者的丘疹、红斑、浸润/肥厚和苔藓化评分比较差异均无统计学意义(P>0.05);治疗组治疗后患者的丘疹、红斑、浸润/肥厚和苔藓化评分均明显低于对照组,差异均有统计学意义(P<0.05);治疗组总有效率为93.88%,明显高于对照组的77.55%,差异有统计学意义(P<0.05);治疗前,两组患者血清IL-4、IL-18和IFN-γ水平比较差异均无统计学意义(P>0.05);治疗组治疗后患者血清IFN-γ和IL-18均明显低于对照组,而IL-4明显高于对照组,差异均有统计学意义(P<0.05).结论 在西医治疗基础上,银屑胶囊治疗慢性湿疹湿热浸淫证可明显改善患者症状、体征,提高其临床疗效,其作用机制可能与降低患者血清IFN-γ、IL-18水平和升高IL-4水平相关.
展开▼
