恩必普注射液联合舒血宁治疗急性脑梗死后失语的疗效观察

摘要

Objective To investigate the clinical effect of butylphthalide injection combined with Shuxuening in-jection in the treatment of aphasia after acute cerebral infarction. Methods One hundred and ninety-two patients with aphasia after acute cerebral infarction during the period from March 2009 to April 2015 in our hospital who met the inclu-sion criteria were selected and assigned to the combination group (n=62) and the control group (n=130) according to their intentions. The combination group was treated with butylphthalide injection (25 mg/time, 2 times/d) and Shuxuening injec-tion (20 ml/time, 1 time/d), while the control group was only treated with shuxuening injection (20 ml/time, 1 time/d). Both groups were treated for 2 weeks. The Aphasia Battery of Chinese (ABC) was used to validate the clinical effect in the two groups before treatment and 90 d after treatment. The results were statistically analyzed. Results There was no statistically significant differences between the two groups in aphasia type, age, gender, education, as well as the scores of main items of ABC (fluency, listening comprehension, repetition and naming) before treatment (all P>0.05). The patients of the two groups showed statistically significant differences in fluency [(51.0±25.1) vs (35.2±18.1)], lis-tening comprehension [(60.2±21.3) vs (47.5±15.6)], repetition [(54.4±18.7) vs (42.1±15.0)] and naming [(44.7±20.2) vs (38.9.±15.4)] than those in control group at 90 d after treatment (all P<0.05). Conclusion Butylphthalide injection com-bined with Shuxuening injection has significant clinical effect on aphasia after acute cerebral infarction.%目的 观察恩必普注射液联合舒血宁治疗急性脑梗死后失语的临床疗效.方法 选取本院2009年3月至2015年4月符合入组条件的急性脑梗死后失语患者192例,按患者意愿分配到联合组和对照组.联合组62例给予恩必普注射液静脉滴注,每次25 mg (100 ml),2次/d,连续14 d;同时静脉滴注舒血宁注射液,每次20 ml, 1次/d,连续14 d.对照组130例则单用舒血宁,用法同联合组.两组患者治疗前及治疗后90d均通过汉语失语成套测验(Aphasia Battery of Chinese,ABC)来评定疗效,并对结果统计学分析.结果 治疗前,两组在失语分型、性别、年龄、文化程度及ABC法主要项目(流利性、听理解、复述及命名)评测的结果比较差异均无统计学意义(P>0.05);治疗后90 d,联合组在流利性、听理解、复述及命名分别为(51.0±25.1)分、(60.3±21.3)分、(54.4±18.7)分和(44.7±20.2)分,对照组分别为(35.2±18.1)分、(47.5±15.6)分、(42.1±15.0)分和(38.9.±15.4)分,两组间以上各项指标比较差异均有统计学意义(P<0.05).结论 恩必普注射液联合舒血宁治疗急性脑梗死后失语疗效显著.