内皮微粒与冠心病关系的研究进展

摘要

Endothelial microparticles (EMPs) are sub-micron particles produced by endothelial cells in various pathological factors. EMPs were found increased in many diseases, especially in cardiovascular disease, and they can re-flect the endothelial function. Recent studies have found that EMPs have all kinds of biological activity, and participate in the formation of coronary heart disease (CHD) in form of thrombosis, inflammation, immune response and intracellu-lar signal transduction. Currently, as a new method for diagnosis of CHD, EMPs also can be used to detect therapeutic ef-fect, and become the therapeutic target for CHD.%内皮微粒(EMPs)是内皮细胞在各种病理因素刺激下产生的亚微米级颗粒,在多种疾病,尤其是心血管疾病状态下升高明显,可以反映内皮功能.近来研究发现EMPs具有各种生物活性,并以血栓形成、炎症、免疫反应及细胞内信号转导等形式参与冠心病(Coronary heart disease,CHD)的发生过程.目前EMPs作为诊断CHD的新方法,还可用于检测CHD的治疗效果,成为CHD的治疗靶点.