零污染空气净化对体外受精-胚胎移植妊娠结局的影响

摘要

Objective To explore the effect of non-pollution-air purification technology on the outcome of in vitro fertilization and embryo transfer (IVF-ET). Methods Two different kinds of air purification systems were used in IVF-ET (group A:the common air purification system;group B:non-pollution-air purification technology). The normal fertilization rate, fertilization rate, cleavage rate, high-quality embryo rate, pregnant rate and early abortion rate were compared between two groups and analyzed using independent sample t test according to age (cut off: 35 years) per group. Results For patients with less than 35 years old, there was no statistical difference between two groups for dura-tion of infertility, the average number of retrieved oocytes, matural oocytes and the number of transplanted embryos (P>0.05). The cleavage rate, high-quality embryo rate and clinical pregnant rate were significantly higher in group B than those in group A, and the early abortion rate was significantly lower in group B than that in group A (P<0.05). For pa-tients with more than 35 years old, there was no statistically significant difference between two groups for duration of in-fertility, the average number of retrieved oocytes, matural oocytes, normal embryos and transplanted embryos (P>0.05). The cleavage rate, high-quality embryo rate and clinical pregnant rate were significantly higher in group B than those in group A, and the early abortion rate was significantly lower in group B than that in group A (P<0.05). Conclusion In Reproductive Center, the non-pollution-air purification system in the laboratory and operation room can effectively im-proved air quality, significantly improve the clinical pregnant rate, and reduce the rate of early abortion rate.%目的 探索零污染空气净化系统对体外受精-胚胎移植(IVF-ET)妊娠结局的影响.方法 分别利用独立样本t检验比较我院生殖中心在应用零污染空气净化系统前(A组:尘埃及细菌滤过空气净化系统)及后(B组:零污染空气净化系统)两组周期不同年龄段(≥35岁和<35岁)的正常受精率、受精率、卵裂率、优胚率、临床妊娠率和早期流产率差异.结果 对于年龄<35岁的IVF-ET患者,应用零污染空气净化系统前后两组不孕年限、平均获卵数、优质卵数和移植胚胎数比较差异均无统计学意义(P>0.05),但实验组优胚率和卵裂率明显提高,与对照组比较差异有统计学意义(P<0.05);显著提高临床妊娠率,降低早期流产率.对于年龄≥35岁的IVF-ET患者,应用零污染空气净化系统前后两组不孕年限、平均获卵数、优质卵数、正常胚胎和移植胚胎数差异均无统计学意义(P>0.05),但实验组优胚率和卵裂率明显提高,与对照组相比差异有统计学意义(P<0.05);显著提高临床妊娠率,降低早期流产率.结论 实验室和手术室使用零污染空气净化系统能明显改善IVF-ET胚胎发育潜能,提高临床妊娠率,有效降低早期流产率.