深圳市未成年人干化学肾功能检测指标参考区间调查

摘要

目的 建立深圳市健康未成年人干化学血清尿素(Urea)、肌酐(Creatinine,Cr)、尿酸(Uric acid,UA)的参考区间.方法 使用干化学分析系统检测1 401例(男760例,女641例) 3个月~18周岁健康未成年人血清标本,分析各年龄、性别组肾功能检测结果.结果 ①7~12岁组的Urea、Cr,13~18岁组的Urea、Cr、UA男、女组间检测结果比较差异均有统计学意义(P<0.05),均为男童高于女童,其余项目男、女童间检测结果比较差异均无统计学意义(P>0.05);②3种项目检测结果均随年龄的增长而增加,不同年龄组间检测结果比较差异均有统计学意义(P<0.05),其中4~6岁组与7~12岁组、7~12岁组与13~18岁组的Urea检测结果比较差异均无统计学意义(P>0.05),其余各年龄间比较差异均有统计学意义(P<0.05);③Urea的参考区间为:3个月~3岁组1.3~6.1 mmol/L、3~18岁组2.1~7.1 mmol/L,Cr的参考区间为:3个月~3岁组14.6~56.5 μmol/L、4~6岁组27.2~52.5 μmol/L、7~12岁组27.5~60.1 μmol/L、13~18岁男童组30.5~103.5 μmol/L、13~18岁女童组29.2~88.6 μmol/L,UA的参考区间为:3个月~6岁组144.6~378.5 μmol/L、7~12岁组165.5~429.9 μmol/L、13~18岁男童组185.9~465.7 μmol/L、13~18岁女童组159.9~429.1 μmol/L.结论 建立起深圳地区健康未成年人干化学肾功能检测指标的参考区间.%Objective To establish the reference intervals of urea, creatinine (Cr), uric acid (UA) on dry chemi-cal system among healthy children and adolescents in Shenzhen. Methods A total of 1 401 blood samples from 760 male and 641 female healthy children and adolescents aged from 3 months to 18 years were collected. Kidney function tests in venous blood were detected by the VITROS 350 system, and data were analyzed by statistical methods. Results ①The urea, Cr of 7~12 years old boys and urea, Cr, UA of 13~18 years old boys were significantly higher than those in girls (P<0.05). The remaining items showed no significant differences between boys and girls (P>0.05).②The reference in-tervals of 3 items were increased with age, showing significant differences in different age groups (P<0.05). However, urea showed no significant difference between 4~6 years group and 7~12 years group, as well as between 7~12 years group and 13~18 years group.③The reference intervals of serum urea were 1.3~6.1 mmol/L for 3 months to 3 years group, 2.1~7.1 mmol/L for 3~18 years group. The reference intervals of Cr were 14.6~56.5 μmol/L for 3 months to 3 years group, 27.2~52.5μmol/L for 4~6 years group, 27.5~60.1μmol/L for 7~12 years group, 30.5~103.5μmol/L for 13~18 years group (male), and 29.2~88.6μmol/L for 13~18 years group (female). The reference intervals of UA were 144.6~378.5μmol/L for 3 months to 6 years group, 165.5~429.9μmol/L for 7~12 years group, 185.9~465.7μmol/L for 13~18 years group (male), and 159.9~429.1μmol/L for 13~18 years group (female). Conclusion The reference inter-vals of urea, Cr, UA were established on dry chemical system among healthy children and adolescents in Shenzhen.