Objective To study the expression vascular endothelial growth factor-C (VEGF-C) in marrow of patients with acute and chronic aplastic anemia. Methods The expression levels of VEGF-C in marrow of patients with acute (38 cases) and chronic (25 cases) aplastic anemia who were treated in the 105th Hospital of Chinese PLA from May 2012 to May 2015 was detected by in situ hybridization, and then compared with those of healthy volunteers (20 cases) Results The expression of VEGF-C in marrow of aplastic anemia was located in the stromal cell, and the positive expres-sion rate was 20.63％. After treatment, the expression of VEGF-C in marrow of patients with acute and chronic aplastic anemia were (139.45 ± 24.39) pg/mL, (134.78 ± 25.24) pg/mL, which were significantly higher than (73.12 ± 20.18) pg/mL, (66.23 ± 21.86) pg/mL before treatment and lower than (170.51 ± 29.64) pg/mL of healthy volunteers after treatment (P<0.05). The expression of VEGF-C showed no statistically significant difference between patients with acute aplastic ane-mia and those with chronic aplastic anemia (P>0.05). Conclusion The expression of VEGF-C in marrow of patients with aplastic anemia is lower than healthy volunteers, and the expression increases after treatment, which indicates that VEGF-C provides a detection index for the diagnosis and treatment of patients with aplastic anemia.%目的 探讨急慢性再生障碍性贫血(AA)患者骨髓血管内皮生长因子-C(VEGF-C)表达的异同及其意义.方法 采用原位杂交法检测63例解放军第105医院2012年5月至2015年5月收治的急性和慢性AA患者免疫抑制剂与激素治疗前后骨髓小粒中VEGF-C的表达情况,其中急性AA 38例,慢性AA 25例,并与20例健康人作对照比较.结果 VEGF-C主要表达于骨髓基质细胞,阳性表达率为20.63％.治疗后急慢性再生障碍性贫血患者骨髓血管内皮生长因子-C[(139.45±24.39)pg/mL、(134.78±25.24)pg/mL]的表达明显高于治疗前[(73.12±20.18)pg/mL、(66.23±21.86)p g/mL],且低于对照组[(170.51±29.64)pg/mL],差异有统计学意义(P<0.05).但急慢性再生障碍性贫血患者骨髓血管内皮生长因子-C(139.45±24.39)pg/mL、(134.78±25.24)pg/mL]比较差异无统计学意义(P>0.05).结论 急慢性AA治疗前VEGF-C表达降低,治疗后VEGF-C表达上调,VEGF-C在疾病治疗转归中可起到重要作用.
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