自拟健脾理气祛瘀方改善糖耐量减低患者胰岛素抵抗的疗效观察

摘要

目的 探讨自拟健脾理气祛瘀方改善糖耐量减低患者胰岛素抵抗的疗效.方法 选择2014年1月至2016年1月期间梅州市中医医院内科诊治的150例糖耐量减低患者为研究对象,根据随机数表法随机分为观察组和对照组,每组75例,对照组予二甲双胍治疗,观察组联合应用自拟健脾理气祛瘀方治疗,疗程均为3个月.比较两组患者治疗前后的空腹血糖(FPG)、餐后2 h血糖(2 hPG)及胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-IS)水平.结果 治疗后,观察组和对照组患者的FPG、2 hPG、HOMA-IR分别为(5.68±0.48)mmol/L、(8.35±2.15)mmol/L、(2.46±0.62)和(6.05±0.62)mmol/L、(9.13±2.08)mmol/L、(2.91±0.57),均较治疗前的(6.51±0.26)mmol/L、(10.48±2.68)mmol/L、(3.81±0.97)和(6.62±0.31)mmol/L、(10.53±2.49)mmol/L、(3.78±0.79)显著降低,HOMA-IS为(21.98±1.98)和(18.64±8.64),均较治疗前的(15.39±5.39)和(16.38±6.38)显著提高,且观察组明显优于对照组,差异均有统计学意义(P<0.05).结论 自拟健脾理气祛瘀方治疗糖耐量降低可以改善胰岛素抵抗,提高胰岛素敏感性.%Objective To study the effect of self-designed Jianpiliqiquyufang in improving insulin resistance in patients with impaired glucose tolerance status. Methods From January 2014 to January 2016, 150 patients with im-paired glucose tolerance treated in Department of Endocrinology of our hospital were selected as the research objects, ac-cording to the random number table method, which were divided into observation group (n=75) and control group (n=75). The control group was treated with metformin treatment, and the observation group received self-designed Jianpiliqiquy-ufang plus metformin treatment. The course of treatment was 3 months. Fasting plasma glucose (FPG), 2 h-postprandial plas-ma glucose (2 hPG) and insulin resistance index (HOMA-IR), islet beta cell function index (HOMA-IS) levels were com-pared between the two groups. Results After treatment, the FPG, 2 hPG, HOMA-IR, HOMA-IS respectively were (5.68 ± 0.48) mmol/L, (8.35 ± 2.15) mmol/L, (2.46 ± 0.62), (21.98 ± 1.98) in the observation group and (6.05 ± 0.62) mmol/L, (9.13 ± 2.08) mmol/L, (2.91±0.57), (18.64±8.64) in the control group, compared with (6.51±0.26) mmol/L, (10.48±2.68) mmol/L, (3.81±0.97), (15.39±5.39) in the observation group and (6.62±0.31) mmol/L, (10.53±2.49) mmol/L, (3.78±0.79), (16.38± 6.38) in the control group before treatment. The levels in the observation group were significantly better than those in the control group (P<0.05). Conclusion Self-designed Jianpiliqiquyufang can reduce insulin resistance, improve insulin sensitivity in impaired glucose tolerance.