非小细胞肺癌颅脑转移的靶向治疗进展

摘要

Brain is one of most common metastatic sites of non-small cell lung cancer(NSCLC).Brain metasta-sis has a high incidence,and implied an extremely poor prognosis.The effect of chemotherapy on brain metastasis from NSCLC is poor due to the blood brain barrier(BBB).With the development of targeted therapy,treatment of brain metasta-sis from NSCLC has now become the research focus in medical oncology.Recently,more and more studies and trials re-garding targeted agents for brain metastases treatment,with a better curative effect were reported.This article make a sum-mary of current situation and progress for targeted therapy for NSCLS with brain metastasis.%颅脑是非小细胞肺癌最常见的远处器官转移部位之一,发生颅脑转移的非小细胞肺癌患者预后较差.由于血脑屏障的存在,化疗对非小细胞肺癌颅脑转移灶的疗效有限.近年来,随着分子靶向治疗的发展,非小细胞肺癌颅脑转移的治疗逐渐成为肿瘤内科研究的重点,评价靶向药物治疗颅脑转移的临床研究不断涌现并取得良好的效果,本文就非小细胞肺癌颅脑转移的靶向治疗的研究进展进行综述.