弥漫性食管痉挛的诊治进展

摘要

Diffuse esophageal spasm(DES)is an uncommon esophageal motility disorder associated with dys-phagia or chest pain.The cause of this disease may be related to esophageal inhibitory neurological dysfunction,esopha-geal muscle thickness increasing,esophagogastric junction relaxation disorder and diaphragmatic diverticulum.But the specific mechanism of DES is still unknown.This paper comprehensive elucidates the latest advancement in pathogene-sis,diagnostis and therapy of diffuse esophageal spam.%弥漫性食管痉挛(DES)是一种以引起吞咽困难或胸痛为主要症状的罕见的食管动力障碍,其病因可能与食管抑制性神经功能障碍、食管肌肉厚度增加、胃食管连接处松弛障碍及膈上憩室相关,但其具体机制目前仍未明确.本文将结合目前关于DES的相关研究,在DES的发病机制、诊断以及治疗方法等方面进行综合论述.