目的 探讨2型糖尿病(T2DM)患者血清铁蛋白(SF)、同型半胱氨酸(Hcy)、空腹生长抑素(FSS)、胰岛素样生长因子-1(IGF-1)与外周动脉病变(PAD)的关系.方法 选取北京天坛医院内分泌科2014年6月至2016年10月收治的160例确诊T2DM患者进行研究,根据踝臂指数(ABI)分组:ABI范围1.0~1.4的患者124例(非PAD组)、ABI范围<1.0的患者46例(PAD组),比较两组患者的血清SF、Hcy、FSS、IGF-1等指标.结果 PAD组患者的年龄、性别、病程、体重指数(BMI)、吸烟率、空腹血糖(FBG)水平与非PAD组比较,差异局均无统计学意义(P>0.05);PAD组患者的收缩压、舒张压、糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平与非PAD组比较,差异均有统计学意义(P<0.05);PAD组患者的血清SF、FSS、IGF-1水平与非PAD组比较,差异均有统计学意义(P<0.05);PAD组的Hcy水平与非PAD组比较,差异局均无统计学意义(P>0.05).采用多元Logistic回归分析结果显示:收缩压、舒张压、HbA1c、HDL-C、SF、IGF-1增高是T2DM患者并发PDA的独立危险因素(P<0.05),FSS、HDL-C水平升高是T2DM患者并发PDA的保护因素(P<0.05).结论 PAD患者与健康人收缩压、舒张压、HbA1c、TC、TG、HDL-C、LDL-C水平有显著差异,SF、IGF-1、HbA1c、FSS水平升高提示PAD在发生发展.%Objective To study the relationship of serum ferritin(SF),homocysteine(Hcy),fasting plasma so-matostatin(FSS),insulin-like growth factor-1(IGF-1)with peripheral arterial disease(PAD)in type 2 diabetes mellitus (T2DM)patients.Methods A total of 160 T2DM patients in our hospital from June 2014 to October 2016 were select-ed and assigned into two groups according to the ankle brachial index(ABI):non-PAD group(ABI range of 1 to 1.4,124 patients), PAD group (ABI<1.0, 46 patients).The levels of SF, Hcy, FSS, and IGF-1 were compared between the two groups.Results PAD group and non-PAD group showed no statistically significant difference in age and sex,course of disease, BMI, smoking rate, the level of FBG (P>0.05), but they showed statistically significant difference in systolic and diastolic blood pressure,HbA1c,TC,TG,HDL-C and LDL-C levels(P<0.05).Levels of SF,FSS and IGF-1 in PAD group were significantly higher than those in non-PAD group(P<0.05),but the level of Hcy were not significantly differ-ent between the two groups(P>0.05).Multivariate logistic regression analysis showed that increased systolic blood pres-sure, diastolic blood pressure, HbA1c, HDL-C, SF and IGF-1 were independent risk factors of PDA in patients with T2DM (P<0.05), and elevated FSS and HDL-C levels were the protective factors of PDA in patients with T2DM (P<0.05).Conclusion Serum levels of SF,FSS,IGF-1 have a certain relationship with PAD in T2DM patients.
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