Objective Retrospectively analyzed the trends of lipid profile in a large Chinese urban population in Nanjing from 2009 to 2015.Methods The total of 236,945 adults (age ≥20 years old)who undertook a health check between 2009 and 2015 in our medical examination center were included in the analysis.Fasting total choles-terol,high-density lipoprotein (HDL)cholesterol,low-density lipoprotein (LDL)cholesterol and triglyceride (TG) were measured by standard methods.Mean values were presented for lipid profile and age-standardized levels of lipid profile were calculated in line with the population distribution in China in 2010.Trends of continuous variables with survey years were determined with linear regression.A two-sided P value less than 0.05 was considered statistically significant.Results An increasing secular trend was observed in LDL cholesterol levels from 2009 to 2015 in both males and females.The LDL cholesterol increased from 2.46 mmol/L (in 2009)to 2.56 mmol/L (in 2015)in males and 2.36 mmol/L (in 2009)to 2.48 mmol/L (in 2015)in females (Pvalues for trends﹤0.01 for both).Further age-specific analysis showed that the increasing trends of LDL cholesterol largely existed in the age groups of 20-39 years and 40~59 years in males rather than in those older than 60 years.The prevalence of either abnormal fasting glucose or abnormal blood pressure was increased with the age groups among the people with dyslipidemia.In people over 70 years old with dyslipidemia,34.4% in males and 30.9% in females complicated with abnormal fasting glu-cose,62.9% in males and 68.5% in females complicated with abnormal blood pressure,respectively.Conclusion Dyslipidemia is an increasing epidemic in urban population in Nanjing,characterized by a rising trend of LDL choles-terol.The trends of lipid profile among different age groups suggested that more attention should be paid to the mid-dle-age men for the management of dyslipidemia and primary prevention of cardiovascular disease.The prevalence of either abnormal fasting glucose or abnormal blood pressure was increased with ages among the people with dyslipi-demia.Thus,it is essential to strengthen the routine screening and monitoring of blood glucose and blood pressure for the elderly.%目的 回顾性分析南京城镇居民 2009—2015 年间的血脂四项变化趋势.方法 纳入 2009—2015 年在我院体检中心检查的 236 954 名成人(年龄≥20 岁),通过标准方法检测空腹静脉血总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C).计算 TC、TG、HDL-C 和 LDL-C 的平均值,并采用 2010 年中国人口分布普查数据来计算年龄标化血脂.不同研究年份的血脂水平趋势用线性回归进行分析.结果 2009—2015 年男性和女性的 LDL-C均呈上升趋势.男性由 2.46 mmol/L(2009 年)上升为 2.56 mmol/L (2015 年),女性由2.36 mmol/L(2009 年)上升为2.48 mmol/L(2015 年)(二者P 值均﹤ 0.001).进一步按年龄分组,男性在 20~39 岁及40~59 岁 LDL-C上升趋势明显,而非 60 岁以上;女性各年龄段的 LDL-C 均呈上升趋势.血脂异常患者中合并血糖或血压异常的比例随着年龄增长而上升.70 岁以上的血脂异常患者中,分别有 34.4%的男性和 30.9%的女性合并血糖异常,62.9%的男性和 68.5%的女性合并血压异常.结论 南京城镇人群血脂异常的患病率呈上升趋势,尤其是血清 LDL-C水平升高趋势明显.不同年龄组患者间的血脂变化趋势提示,中年男性应该作为控制血脂异常和早期预防心血管病的首要目标.血脂异常患者中,合并血糖或血压异常的比例随年龄增长而上升,应加强对于高龄血脂异常患者血糖及血压的常规筛查与监测.
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