宫颈癌术后两种放疗模式的剂量学比较研究

摘要

目的 比较常规四野箱式放疗(4F-CRT)、调强放疗(IMRT)对宫颈癌术后放疗剂量学优缺点.方法 选取存在高危因素宫颈癌术后患者50例，放疗前进行CT扫描并进行靶区勾画，每位患者分别进行4F、IMRT两套计划，给予相同的处方剂量，通过DVH图比较两种治疗技术对计划靶体积(PTV)及正常器官剂量分布情况进行研究.结果 在计划靶体积(PTV)调强的靶区覆盖要优于四野放疗(P<0.05)，但两种治疗技术均可提供满意的剂量覆盖，在直肠、乙状结肠、膀胱、小肠的受照射体积及平均剂量调强均低于4F(P<0.05).结论 对于计划靶体积(PTV)，两种计划均有较好的覆盖，而IMRT较4F可获得更好的靶区剂量分布并更有利于直肠、乙状结肠、小肠及膀胱保护.%　　Objective To compare the dosimetric advantages and disadvantages of box field work(4F-CRT) and intensity-modulated radiotherapy(IMRT) plans for patients with cervical cancer after radical hysterectomy. Methods 50 cases of cervical cancer were enrolled.CT would be accepted before radiotherapy and the targets would be delineated. Three plans,that is,4F-CRT and IMRT,were designed for each patient simultaneously with the same prescription dose.The compare histogram DVH cure to oberve the PTV and endanger organ. Results All two treatment plannings could provide quite good dose distributions,but the prescribed dose corverage with IMRT were all superiar to 4F-CRT(P<0.05). Compared with 4F ,IMRT reducing the volume and the mean dose to small intestine,bladder and rectum(P<0.05).Conclusion  All two treatment plannings havegood coverage to the PTV  but well—protection to the surrounding organs,especially rectum,sigmoid,intestine and bladder.