四氢叶酸钙不同解救方法治疗成人难治复发性急性淋巴细胞白血病的研究

摘要

目的本文主要就四氢叶酸钙不同解救时间治疗成人难治复发性急性淋巴细胞白血病的效果展开分析讨论。方法收集2010年1月至2012年1月期间，在我院就诊的35例难治复发性急性淋巴细胞白血病患者，并将其随机分成两组，对对照组20例患者在MTX静脉滴注后的12h以CF进行解救；对实验组15例患者在MTX静脉滴注后的20h以CF进行解救。观察两组的毒副作用和疗效。应用荧光免疫偏振分析法(FPIA)测定血清MTX浓度。结果两组毒副作用和恢复时间及完全缓解率比较均无显着性差异（P>0.05），但在随访期内常规组4例出现复发，试验组仅2例复发。结论对HDMTX方案推迟解救不会增加相关毒副作用的发生率和严重程度，且可提高治疗效果。%Objective This paper is mainly on the different time of leucovorin rescue treatment of refractory and relapsed adult acute lymphoblastic leukemia effect analysis and discussions. Methods From 2010 January to 2012 January in our hospital, 35 cases of refractory and relapsed acute lymphocytic leukemia patients, which were divided into two groups, the control group of 20 patients in MTX after intravenous infusion for 12 hours to rescue CF;the experimental group of 15 patients in MTX intravenous 20 hours after injection with CF rescue.To observe two groups of toxic side effects and efficacy. Application of immune fluorescence polarization analysis method for determination of serum MTX(FPIA). Results The two groups of toxic effects and recovery time and complete remission rate was no significant difference(P>0.05), but during the follow-up period the conventional group 4 cases recurred in only 2 cases of recurrence, the test group. Conclusion The HDMTX delayed rescue scheme does not increase the associated side-effect incidence and severity, and can improve the treatment effect.