乙胺丁醇治疗糖尿病并肺结核对视神经的影响分析

摘要

目的：探讨乙胺丁醇治疗糖尿病合并肺结核对视神经的影响。方法收集我院2012年1月至2015年1月收治的糖尿病合并肺结核患者120例，患者根据乙胺丁醇剂量不同分为高剂量（1.25 g/d）、中剂量（1.00 g/d）和低剂量组（0.75 g/d），每组30例，患者均给予降糖药物、营养支持治疗以及常规护理措施，经过相同时间观察患者视神经变化。结果高剂量组视神经损伤率为35.0%（14/40），中剂量组为22.5%（9/40），低剂量组为10.0%（4/40），差异具有统计学意义（P<0.05），其中高剂量组与低剂量组视神经损伤率差异具有统计学意义（P<0.05）；视功能下降时间、视力下降水平在三组间差异具有统计学意义（P<0.05），其中高剂量组与低剂量组视功能下降时间、视力下降水平差异均具有统计学意义（P<0.05）。结论乙胺丁醇治疗糖尿病并肺结核对视神经有一定损伤，并且剂量越高损伤可能越大。%ObjectiveTo explore the inlfuence of ethambutol on optic nerve in the treatment of diabetes complicated with tuberculosis.Methods120 cases of diabetes complicated with tuberculosis were collected and divided into high dose group (1.25 g/d),median dose group(1.00 g/d) and low dose group(0.75 g/d) with 30 cases in each group.Patients were treated with hypoglycemic drugs,nutritional support treatment and routine nursing measures,the changes of optic nerve were observed after same period of time.ResultsThe optic nerve damage rate of high-dose group was 35.0%,of median-dose group was 22.5%,of low-dose group was 10.0%,wherein that of high-dose group and low dose group was statistically different (P<0.05); visual function decline time,vision decreased level of three groups were statistically different (P<0.05) and those of high-dose group and low dose group were statistically different (P<0.05). ConclusionEthambutol treatment of diabetes complicated with tuberculosis has some damage to the optic nerve,and the higher the dose the greater the likely damage.