老年人血尿酸与阿尔茨海默病的相关性探讨

摘要

目的：探讨老年人血尿酸（serum uric acid，SUA）水平与阿尔茨海默病（Alzheimer＇s disease，AD）的相关性。方法选择227例我院老年病科住院患者为研究对象，其中阿尔茨海默病67例，其余160例为非 AD 组。收集病史、吸烟史、服药史，并检测血尿酸、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、空腹血糖（FBS）、血肌酐（Cr）水平。比较各 SUA 四分位数水平 AD 的发生率，并进行相关性分析。结果AD 组血尿酸水平低于非 AD 组，差异有统计学意义（P ＜0.01）；多因素分析筛选出年龄、性别、缺血性脑卒中是危险因素（P ＜0.05），而服用他汀、SUA、HDL-C 是保护因素（P ＜0.05）。对 AD 和 SUA 的四个分组做 Spearman 等级相关分析（rs ＝-0.285，P ＜0.001），结果呈等级负相关。结论血尿酸水平与老年人 AD 相关，血尿酸可能是 AD 发病的保护性因素。%Objective To explore the correlation between serum uric acid (SUA)level and Alzheimer's disease (AD)in elderly patients. Methods 67 cases of the elders with Alzheimer's disease and 160 elders matching with age and gender were enrolled from Jan 2013 to Dec 2014 in the study,the blood levels of biochemical factors such as SUA,total choles-terol (TC),triglycerides (TG),low-density lipoprotein cholesterol (LDL-C),high-density lipoprotein cholesterol (HDL-C),fasting blood sugar (FBS)and creatinine (Cr)were measured by automatic biochemistry analyzer in the two groups.The related factors such as history of disease,smoking and medication history were collected.The correlation between the level of SUA and AD was analyzed. Results The serum uric acid levels in AD group were significantly lower than those in control group (P <0.01).Multivariate logistic regression analysis showed that age,gender,ischemic stroke were risk factors,and taking statin,SUA,and HDL-C were protective factors (P <0.05).Spearman correlation tests indicated that there was an in-verse correlation between SUA levels and AD (rs =-0.285,P <0.001). Conculsion Serum uric acid level is significantly related to AD in the elderly.SUA may be a protective factor of the occurrence of AD.