2型糖尿病并视网膜病变患者血浆趋化素水平与骨密度的关系

摘要

Objective To explore the relationship between the circulation level of chemerin level and bone mineral density(BMD)in type 2 diabetes retinopathy patients.Methods A total of 150 patients with type 2 diabetes were selected.They were divided into two groups: retinopathy group(DR group), non-retinopathy group(NDR group).HbAlc, triglycerides(TC), total cholesterol(TG), low density lipoprotein cholesterol(LDL-C)and high-sensitivity C-reactive protein(hs-CRP)was measured by automatic biochemical detector.Bone mineral density was measured by the dual-energy X-ray absorptiometry.The BMD of lumbar vertebrae 2-4 and the left side of the femoral neck, the greater trochanter and Ward's triangle were assessed.Results ①Compared with the NDR group, the duration of diabetes in group DR was significantly longer%目的 初步研究2型糖尿病并视网膜病变患者的血浆趋化素(chemerin)水平及其与骨密度的关系.方法 选择150名糖尿病患者,按视网膜病变分为视网膜病变组(DR组)和眼底正常对照组(NDR组),采用全自动生化检测仪测定糖化血红蛋、甘油三脂、总胆固醇、低密度脂蛋白、高敏C反应蛋白;使用ELISA法检测血浆chemerin水平.骨密度采用双能X线骨密度仪分别测定腰椎正位(L2、L3、L4)、左侧股骨颈、大粗隆区、Ward`s三角区的骨密度.结果 ①与NDR组相比,DR组的糖尿病病程较NDR组显著延长(P<0.05).②DR组的TC、LDL-C、HbA1c、hs-CRP、chemerin水平较NDR组均显著升高(P<0.05).③DR组的股骨颈、大粗隆区、Ward`s三角区的骨密度较NDR组显著降低(P<0.05).④血清chemerin水平与病程、BMI、HbA1C呈正相关,与股骨颈、大粗隆区、Ward`s三角区的骨密度呈负相关.结论 DR患者的chemerin显著升高,chemerin可能参与DR的发生发展,并可能促使DR患者的骨密度降低.