The amphiphilic chitosan derivative was synthesized regioselectively , O'O -lauroyl chitosan ( O'O -LCS) was achieved by the selective protection of amino groups in methylsulfonic acid , and degree of substitution ( DS) of O'O-LCS was receive by elemental analysis.The O'O-LCS was characterized by FTIR and 1H-NMR.The results showed that lauroyl groups were successfully grafted on chitosan and receiving desired DS .%利用壳聚糖在甲磺酸溶剂中与月桂酰氯进行酰化反应,得到羟基上取代的O'O-月桂酰基壳聚糖本实验制备了壳聚糖。通过元素分析计算产品的取代度,并对其进行了IR、1 H-NMR表征。结果表明,通过此法月桂酰基能成功地接到了壳聚糖的羟基上,并获得较高的取代度。
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