广西壮族非小细胞肺癌患者FHIT基因表达的研究

摘要

Objective To investigate the expression of FI-lIT gene in non-small cell lung cancer( NSCLC )in Guangxi Zhuang nationality,and to analysis the relationship between clinicopathologic factors. Methods The expressions of FI-lIT were detected by RT-PCR in 56 cases of lung cancer and 20 normal lung tissues in Guangxi Zhuang nationality.Results NSCLC cancer deletion rate of FHIT gene was 69.6％( 39/56 ),which was higher than that of nomal lung tissue 0 ( 0/20 ),the difference was significant ( P＜0.01 );The lack of FI-I1T gene was associated with smoking,histological type,lymph node metastasis and clinical stage( P＜0.05 ). Conclusion The deletion of FHIT gene is closely correlated to the genesis of lung cancer. Smoking results in an increased rate of the deletion of FHIT gene and increases the incidence of lung cancer.%目的 探讨广西壮族NSCLC患者中FHIT基因的表达情况,并分析其与临床病理因素的相互关系.方法 利用RT-PCR法检测56例广西壮族NSCLC患者组织和20例正常肺组织中FHIT的表达情况.结果 NSCLC癌组织中FHIT基因缺失率为69.6%(39/56),而正常肺组织中FHIT基因缺失率为0(0/20),两者比较差异有统计学意义(P＜0.01);FHIT基因缺失与吸烟、病理类型、淋巴结转移和临床分期有关(P＜0.05).结论 FHIT缺失与肺癌的发生发展关系密切,吸烟致使FHIT基因缺失率增加,肺癌的发病率升高.