鼻咽癌组织中VEGF-C表达与淋巴管密度的相关性分析

摘要

Objective To investigate Lho correlation botwoon vascular ondoLholial growlh factor C( VEGF-C ) and lymphaLic vessel density ( LVD) in patients With nasopharyngeal carcinoma. Methods Immunohistochemistry ( 111C ) was used to examine the expression of VEGF-C in 56 nasopharyngeal carcinoma cases( NC group ) and 15 normal mucous membrane of nasopharynx cases( conLrol group ),and Lhon LYVE-1 sLaining was used Lo counL LVD in nasopharyngeal carcinoma. CorrelaLion botwoon VEGF-C and LVD was analyzed in MC group. Results The positive raLo of VEGF-C in MC group was 83. 9%( 47/56 ),which was significantly higher than that [26.7%(4/15 ) ] in the control group( P <0. 05 ). LVD in MC gmup was significantly higher than that in the control group( 20.00 ±4.37/IIP vs 0.12 ± 1. 79/IIP.P <0.05 ). The expression of VEFGC was positively correlated with LVD in MC group( P <0. 01 ). Conclusion The expression of VEGF-C is positively correlated with LVD,and VEGF-C may stimulate lymphatic formation.%目的 探讨鼻咽癌组织中血管内皮生长因子-C(VEGF-C)与淋巴管密度(LVD)的相关性.方法 采用免疫组化方法 检测56例鼻咽癌标本(鼻咽癌组)和15例正常鼻咽黏膜标本(对照组)中VEGF-C的表达情况,并通过淋巴管内皮透明质酸酶受体-1(LYVE-1)染色,计数鼻咽癌组淋巴管密度(LVD)值,分析鼻咽癌组VEGF-C与LVD的相关性.结果 鼻咽癌组VEGF-C阳性表达率为83.9%(47/56),高于对照组的26.7%(4/15)(P＜0.05);鼻咽癌组LVD值为(20.00±4.37)个/高倍镜视野,明显高于对照组的(0.12±1.79)个/高倍镜视野(P＜0.05).鼻咽癌组LVD与VEGF-C的表达呈正相关(P＜0.01).结论 VEGF-C表达与LVD呈正相关关系,鼻咽癌中VEGF-C的表达能促进淋巴管的生成.