目的 探讨子宫内膜癌组织中γ-synuclein表达与子宫内膜癌预后的关系.方法 采用免疫组化S-P法检测63例子宫内膜癌组织及12例正常子宫内膜组织中γ-synuclein的表达.结果 子宫内膜癌组织中γ-synuclein阳性表达率为44.4%(28/63),正常子宫内膜组织无表达,差异有统计学意义(P＜0.05).γ-synuclein阳性表达组总体生存率为97.1%,高于阴性表达组的35.7%,差异有统计学意义(P＜0.05);Cox多因素分析显示γ-synuclein、浸润深度与子宫内膜癌预后有关(P＜0.05).结论 γ-synuclein表达与子宫内膜癌发生发展及侵袭转移有关,可能对患者预后有提示作用.%Objective To investigate the expression of γ-synuclein in endometrial carcinoma and its relationship with the prognosis of endometrial carcinoma. Methods Immunohistochemical method was used to detect the expression of γ-synuclein in 63 samples of endometrial carcinoma and 12 cases of normal endometrium tissues. Results The positive rate of γ-synclein exression in endometrial carcinoma was 44.45%(39/63)while no expression of γ-synuclein in normal endometrium tissues,which showed significant different between the two groups(P＜0.05).The total surivival of the group of positive expression of γ-sunuclein was significantly higher than that of the group of negative expression of γ-synuclein(97.1%vs 35.7%,P＜0.05).The Cox multivariate analysis showed that γ-synuclein,the depth of myometrial invasion was associated with the prognosis of endometrial carcinoma(P＜0.05).Conclusion The expression of γ-synuclein is related with the progression,invasion and metastasis of malignant endometrial carcinoma,and it may suggest poor prognosis.
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