目的：探讨血清血管生成素1、2（ Ang-1、Ang-2）及低氧诱导因子1α（ HIF-1α）在烟雾病发生发展中的作用。方法烟雾病患者38例（烟雾病组），健康体检者40例（对照组），采用酶联免疫吸附法检测两组血清Ang-1、Ang-2及HIF-1α浓度。结果烟雾病组Ang-1浓度低于对照组（ P＜0．05），两组Ang-2、HIF-1α浓度比较，差异无统计学意义（ P＞0．05）；不同性别、不同发病类型的烟雾病患者血清Ang-1、Ang-2及HIF-1α浓度比较，差异均无统计学意义（P＞0．05）；不同数字减影血管造影（DSA）铃木分期Ang-1、HIF-1α浓度比较，差异有统计学意义（ P＜0．05），但Ang-2浓度比较，差异无统计学意义（ P＞0．05）。结论 Ang-1可能参与了烟雾病的发生发展，HIF-1α可能与颅底烟雾病的发生有关。%Objective To investigate the role of serum angiopoietin 1,2( Ang-1,Ang-2) and hypoxia-inducible factor 1α( HIF-1α) in the occurrence and development of moyamoya disease .Methods Thirty-eight cases of moyamoya disease ( moyamoya disease group ) and 40 healthy cases ( control group ) were detected for serum Ang-1,Ang-2 and HIF-1αconcentrations with enzyme-linked immunosorbent assay (ELISA).Results The Ang-1 concentration in moyamoya disease group was lower than the controls (P<0.05).There was no significant difference in the concentrations of Ang-2, HIF-1αbetween two groups(P>0.05).The concentrations of Ang-1,Ang-2 and HIF-1αshowed no significant difference among moyamoya disease patients of different genders or different types of the disease ( P>0.05).The concentrations of Ang-1 and HIF-1αwere associated with disease stages (P<0.05),while the Ang-2 concentration was not (P>0.05). Conclusion Ang-1 may be involved in the occurrence and development of moyamoya disease .HIF-1αmay be associated with the occurrence and development of moyamoya disease .
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