人芽囊原虫病患者外周血细胞因子测定及其意义

摘要

目的：研究白细胞介素-8（IL-8）、白细胞介素-18（IL-18）、粒-巨噬细胞集落刺激因子（GM-CSF）在人芽囊原虫病中的作用。方法用酶联免疫吸附试验（ELISA）测定30例人芽囊原虫病患者外周血中IL-8、IL-18、GM-CSF水平，并与正常对照组进行比较。结果人芽囊原虫病患者外周血中IL-8、IL-18、GM-CSF水平显著高于正常对照组（ P ＜0．05）。 IL-8、GM-CSF 水平随感染程度加重而升高（ P ＜0．05）。结论 IL-8、IL-18、GM-CSF可能在人芽囊原虫感染发病中发挥作用。%Objective To investigate the role of interleukin-8 ( IL-8 ) , interleukin-18 ( IL-18 ) , granulocyte-macrophage colony-stimulating factor ( GM-CSF ) in Blastocystis hominis .Methods The levels of IL-8 , IL-18 , GM-CSF in peripheral blood of 30 cases of Blastocystis hominis were measured with enzyme-linked immunosorbent assay (ELISA).And the levels were compared with the normal controls .Results The levels of IL-8,IL-18,GM-CSF in peripheral blood of patients with Blastocystis homini were significantly higher than those of normal control group (P<0.05).The levels of IL-8,GM-CSF increased with increasing severity of infection (P <0.05).Conclusion IL-8 ,IL-18 ,GM-CSF may play an important role in the pathogenesis of Blastocystis hominis infection .