鼠神经生长因子联合地塞米松乳突骨膜下注射治疗突发性耳聋效果评价

摘要

Objective To investigate the therapeutic effect of mastoid subperiosteal injection of nerve growth factor of rats combined with dexamethasone in the treatment of sudden deafness (SD).Methods Eighty cases of patients(86 ears) with SD were divided into control group(38 cases,42 ears)or experimental group(42 cases,44 ears) in accordance with random number table.Both the two groups were given conventional therapy,with the control group were additionally administered with nerve growth factor of rats by muscle injection and dexamethasone by intravenous infusion,while the experimental group were treated with nerve growth factor of rats combined with dexamethasone by mastoid subperiosteal injection.The clinical treatment effect was compared between the two groups .Results The total effective rate in the experimental group was 93.18%,significantly better than 71.43%in the control group(P<0.05).After treatment,both air conduction and bone conduction thresholds in the experimental group were significantly decreased,and lower compared to the control.The incidence rate of adverse reactions in the experimental group was 11.90%,slightly lower than that of 23.68%in the control group(P>0.05).Conclusion For patients with SD,the efficacy of nerve growth factor of rats combined with dexamethasone by mastoid subperiosteal injection is remarkable ,since it can effectively improve the hearing thresholds,with less adverse reactions,implying its broad clinical application.%目的：观察鼠神经生长因子联合地塞米松乳突骨膜下注射治疗突发性耳聋（ SD ）的效果。方法将80例（86耳）SD患者按照随机数字表法分为对照组38例（42耳）和试验组42例（44耳），两组均给予常规治疗，对照组给予肌肉注射鼠神经生长因子联合静脉滴注地塞米松治疗，试验组给予鼠神经生长因子联合地塞米松乳突骨膜下注射治疗。对比临床治疗效果。结果试验组总有效率为93．18％，优于对照组的71．43％（P＜0．05）；治疗后试验组空气传导及骨传导听阈值明显低于治疗前，且低于对照组（P＜0．05）；试验组不良反应发生率为11．90％，略低于对照组23．68％（P＞0．05）。结论对SD患者采用鼠神经生长因子联合地塞米松乳突骨膜下注射治疗效果显著，可有效改善听阈值，不良反应少，可在临床中大力推广使用。