婴幼儿反复呼吸道感染与维生素D缺乏的关系

摘要

目的 探讨婴幼儿反复呼吸道感染(RRI)与维生素D缺乏的关系.方法 选择RRI婴幼儿200例(观察组)及非RRI婴幼儿100例(对照组),比较两组25-羟维生素D3[25-(OH)D3]水平及其缺乏发生率.对维生素D缺乏或不足的观察组患儿给予补充维生素D,比较治疗前后血清25-(OH)D3水平及RRI发生情况.结果 观察组不同年龄段患儿血清25-(OH)D3水平均低于对照组,维生素D缺乏症发生率均高于对照组(P<0.05);补充维生素D后观察组各年龄段患儿25-(OH)D3水平均高于治疗前,呼吸道感染发生次数减少(P<0.05).结论 维生素D缺乏可能与婴幼儿RRI发生有关,补充维生素D对预防RRI可能有一定的作用.%Objective To explore the relationship between recurrent respiratory infection (RRI) and vitamin D deficiency in infants.Methods A total of 200 infants with RRI(observation group) and 100 infants without RRI(control group) were enrolled in the study.The level of 25-hydroxyvitamin D3[25-(OH)D3] and the incidence of 25-(OH)D3deficiency were compared between the two groups.The infants with vitamin D deficiency/insufficiency in the observation group were given vitamin supplement,and the level of serum 25-(OH)D3and the incidence of RRI before and after treatment were compared.Results In the observation group,the levels of serum 25-(OH)D3of infants with different ages were lower and the incidence rate of vitamin D deficiency was higher compared to those in the control group (P<0.05).After vitamin D supplement,the level of 25-(OH)D3of infants in all age groups was higher than that before treatment in the observation group,and the incidence of respiratory tract infection decreased (P<0.05). Conclusion Vitamin D deficiency may be associated with the incidence of RRI in infants,and vitamin D supplement might have a certain role in the prevention of RRI.