PCR法及液基薄层细胞学检测诊断宫颈癌变效能比较及其相关性

摘要

Objective To explore the efficiency and correlation between Thinprep cytology test(TCT) and PCR for the diagnosis of cervical carcinogenesis.Methods A total of 200 patients pathologically diagnosed as cervical carcinogenesis and 100 healthy subjects were enrolled.All subjects received TCT and PCR detection.Receiver operating characteristic(ROC) curve was constructed to compare the diagnostic efficiency between TCT and PCR in the diagnosis of cervical carcinogenesis.Correlation of detection results between TCT and PCR was analyzed among subjects with cervical carcinogenesis.Results The areas under ROC curve for TCT and PCR in the diagnosis of cervical carcinogenesis were 0.817 and 0.926 respectively(P＜0.05).The area under ROC curve for PCR was higher than that for TCT (P＜0.05).There was a positive correlation between the detection results of TCT and PCR(P ＜0.05). Conclusion The detection results of the two methods present a positive correlation,however,the efficiency of PCR is superior to that of TCT in the diagnosis of cervical carcinogenesis.%目的 液基薄层细胞学检测(TCT)与PCR法在宫颈癌诊断中的效能及相关性.方法 选择200例经病理活检确诊的宫颈癌变患者及100例健康受试者,所有受试者均进行TCT及PCR法检测.构建两种方法诊断宫颈癌变的受试者工作特征(ROC)曲线比较二者的诊断效能;分析宫颈癌变受试者中TCT与PCR法检测结果的相关性.结果 TCT法和PCR法诊断宫颈癌变的 ROC 曲线下面积分别为0.817和0.926(P ＜0.05),PCR 法的 ROC 曲线下面积高于 TCT 法(P＜0.05).TCT与PCR法的检测结果呈正相关(P＜0.05).结论 两种方法的检测结果呈正相关,但PCR法诊断宫颈癌变的效能优于TCT法.