多囊卵巢综合征患者胰岛素抵抗与载脂蛋白B/载脂蛋白A1比值的相关性

摘要

目的 探讨多囊卵巢综合征(PCOS)患者胰岛素抵抗(IR)与载脂蛋白B/载脂蛋白A1(ApoB/ApoA1)比值的关系.方法 570例PCOS患者,满足糖耐量异常、糖尿病、空腹血糖∶空腹胰岛素比值(G:I)<4.5 mg/10-4 U 3个条件中任1个即诊断为IR.结果 与低ApoB/ApoA1比值组相比,高ApoB/ApoA1比值组患者IR更严重(P<0.05);高ApoB/ApoA1比值组较低ApoB/ApoA1比值组发生IR的风险优势比为2.27(P<0.05).结论 PCOS患者发生IR的严重程度及风险随着 ApoB/ApoA1 比值的升高而增高.%Objective To assess the correlation between insulin resistance ( IR ) and the ApoB/ApoAl ratio in polycystic ovary syndrome ( PCOS ) patients. Methods Anthropometric measurements and biochemical parameters were assessed in 570 PCOS patients. The high ApoB/ApoAl ratio was defined as the upper quartile of the ApoB/ApoAl ratios ( ≥0.68 ), as the remaining three quartiles were merged into the low ApoB/ApoAl ratio. IR was diagnosed if the patients met at least one out of the following three criteria: ( 1 ) impaired glucose tolerance ( IGT ), ( 2 ) DM, ( 3 ) the fasting serum G: I ratio ( G:I) less than 4. 5 mg/10 -4 U. Results The percentage of patients with IR was significantly greater in the high ApoB/ApoAl ratio group than that in the low ApoB/ApoAl ratio group. Furthermore, patients in the high ApoB/ ApoAl ratio group were 2. 27 times more likely to get IR than those in the low ApoB/ApoAl ratio group. Conclusion The severity and risk of IR gradually increase as the ApoB/ApoAl ratio elevated in the young PCOS patients.