常见中药复方制剂抗肝纤维化机制研究进展

摘要

中药复方制剂具有多层次、多途径、多靶点抗肝纤维化的整体治疗优势,目前对中药复方制剂抗肝纤维化机制的研究仍然集中在通过各种途径抑制HSC增殖和活化、减少ECM的合成、加快细胞凋亡、抗脂质过氧化等方面.如何获得中药复方制剂抗肝纤维化的最大效益,需要运用细胞分子生物学、基因技术等手段对其抗肝纤维化机制进行进一步研究.%There is a advantage for Chinese patent medicine to treat hepatic fibrosis by measures of multi-level, multi-channel, multi-target. At present, antifibrotic mechanism research of Chinese patentrnECM , accelerating cell apoptosis, resisting lipid peroxidation through a variety of channels and so on. How-to get the maximum benefit of Chinese patent medicine antifibrotic requires the use of cellular and molecularrnbiology, gene technology and other means to further study its antifibrotie mechanism.