糖尿病周围神经病变是糖尿病所致神经病变中最常见的一种，影响患者的生活质量。中医药治疗糖尿病周围神经病变有一定的优势。其中补肾活血治疗糖尿病周围神经病变得到了一定程度的认可。在改善患者症状和中医证候积分，消除或减轻神经体征，促进神经运动传导速度及感觉传导速度的改善有明显的优势。近年来补肾活血治疗糖尿病周围神经变机制的研究热点在非酶促糖基化、氧化应激、神经损伤修复以及炎性反应，补肾活血法在上述机制中均有积极影响。但也存在临床研究范围局限、说服力不强、年龄对证型的影响、实验研究观察指标不全面、血清药理学方法制备含药血清的局限性等问题。%Diabetic peripheral neuropathy is one of the most common diabetes-induced neuropa-thies. It affects the quality of patients’ life. There are some certain advantages in the Chinese medicine treatment of diabetic peripheral neuropathy. The Bushen Huoxue treatment of diabetic peripheral neuropa-thy has received a certain degree of recognition by Chinese medicine. There are some obvious advantages in improving symptoms and TCM syndrome score, eliminating or reducing neurological signs, promoting the improvement of nerve conduction velocity and sensory conduction velocity. In recent years, the diabetic pe-ripheral neuropathy treatment of Bushen Huoxue mechanisms focused on non-enzymatic glycosylation, oxi-dative stress, nerve repair and inflammatory reactions. Bushen Huoxue has a positive impact in these mech-anisms. However, there are some problems such as limitations of the scope of clinical research,the impact of age on TCM syndromes, experimental study of simple observed indicators, limitations of serum pharma-cological method for preparing drug-containing serum.
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