目的 探讨老年糖尿病患者血清Apelin水平与尿白蛋白排泄率的相关性,为老年糖尿病肾病的预治提供临床依据.方法 59例年龄在65岁以上的糖尿病患者和30例同年龄段健康对照者,采用酶联免疫吸附法测定空腹血清Apelin含量,同时检测空腹血糖及24小时尿白蛋白排泄率(UAER),分析其相关性.结果 59例糖尿病患者血清Apelin值为473±64.34,UAER为87.34±44.32,两者呈在非常显著的正相关(r=0.384,P＜0.01).而对照组两指标无相关性.同时糖尿病组和对照组的血清Apelin水平与血糖值之间也无明显相关性.结论 老年糖尿病患者血清Apelin升高与UAER密切相关,提示血清Apelin水平可能是糖尿病肾病发生的因素之一.%Objective To investigate the relationship between the level of Apelin in serum and urinary albumin excretion rate (UAER) in aged diabetes mellitus and to provide the clue and evidence of early diagnosis and treatment in diabetic nephropathy. Methods Samples of 59 inpatients and 30 healthy persons over 65 years old were collected. Apelin levels in patient blood serum were assayed by ELISA. UAER and Fasting Plasma Glucose (FPG) had also been measured. Associations between these indexes were analysed. Results Average Serum Apelin levels of diabetes mellitus of 59 cases was 473 ±64.34 and average UAER was 87.34±44.32. There was significant association between these two indexes (r=0.384, P<0.01) in diabetes mellitus group but not in control. In addition, no significant association between serum Apelin level and FPG was found in two groups. Conclusion serum Apelin lewel has a association with UAER in aged diabetes mellitus and Apelin may be involved in development of diabetic nephropathy.
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