目的:探讨PAX2在Ⅰ型子宫内膜癌中的表达,分析其在Ⅰ型子宫内膜癌发病机制中的作用.方法:采用免疫组化法检测61例子宫内膜癌、35例子宫内膜增生、19例子宫内膜不典型增生及17例正常增殖期子宫内膜中PAX2的表达情况. 结果:(1) PAX2的表达在不典型增生内膜、Ⅰ型子宫内膜癌与正常增殖期子宫内膜之间;不典型增生内膜、Ⅰ型子宫内膜癌与子宫内膜增生之间;不典型增生内膜、Ⅱ型子宫内膜癌与Ⅰ型子宫内膜癌之间差异均有统计学意义(P<0.05). 而PAX2的表达在正常增殖期子宫内膜、子宫内膜增生、Ⅱ型子宫内膜癌之间两两比较均无差异(P>0.05).(2)61例子宫内膜癌中,有淋巴结转移的患者其PAX2的表达明显高于无淋巴结转移的患者(P<0.05),差异有统计学意义. 而PAX2的表达与患者的年龄、分化程度以及肌层浸润情况均无关(P>0.05). 结论:PAX2基因可能在Ⅰ型子宫内膜癌癌变的机制中扮演了重要的角色,并可以成为鉴别子宫内膜过度增生以及不典型增生的染色指标.%Objective: To investigate the expression of PAX2 in endometrial carcinoma and precancer , and analyze the role of PAX2 play in the pathogenesis of type I endometrial carcinoma. Methods: The expression of PAX2 was detected by immunohistochemical staining in 61 cases endometrial carcinoma, 35 cases endometrial hyperplasia,19 cases atypical endometrial hyperplasia and 17 cases of normal proliferative endometrium. Results:(1) Between atypical endometrial hyperplasia,typeⅠendometrial carcinoma and normal proliferative endometrium, atypical endometrial hyperplasia, typeⅠendometrial carcinoma and endometrial hyperplasia, atypical endometrial hyperplasia, typeⅡendometrial carcinoma and type I endometrial carcinoma, the positive expression of PAX2 have significant differences (P>0.05).However,there were no differences among normal proliferative endometrium, endometrial hyperplasia and typeⅡendometrial carcinoma(P<0.05).(2) The positive expression of PAX2 in patients with lymph node metastasis was significantly higher than that in patients without lymph node metastasis (P<0.05), but there were no associations can be seen between expression of PAX2 with age, histological grade and myometrial infiltration . Conclusion: PAX2 gene may play an important role in the pathogenesis of type I endometrial carcinoma,and which can be as a maker for diagnosis of endometrial hyperplasia and atypical endometrial hyperplasia.
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