Pituitary tumors not only can be the main cause of various endocrine symptoms, but also have a major effect on sexual development and function. The link between functional pituitary adenomas and sexual functions is gradually accounted at clinical level. The mechanism may be correlated with the impairment of the hypothalamic-pituitary-gonadal axis. Pituitary tumors firstly should be treated. Then, supplement testosterone or phosphodiesterase 5 inhibitors may be used to treat sexual dysfunction. The aim of this review was to summarize the latest progress about the incidence, clinical symptoms, pathogenesis, diagnosis and treatment of sexual dysfunction in patients with pituitary adenoma.%功能性垂体腺瘤不仅会产生内分泌紊乱的症状,而且常引发性功能障碍.功能性垂体瘤与性功能之间的关系逐渐得到重视,其发生机制可能与垂体肿瘤影响下丘脑-垂体-性腺轴有关.治疗上应首先治疗垂体肿瘤原发病,在肿瘤被切除或控制后,则可选择补充睾酮或应用磷酸二酯酶5型抑制剂治疗性功能障碍.本文就功能性垂体腺瘤患者性功能障碍的发病率、临床表现、发病机制、诊断及治疗的最新研究进展作一综述.
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