普洱茶对高脂血症大鼠血脂、血浆中血栓B_2、6-酮前列腺素F_（1α）水平影响

摘要

In order to establish a hyperlipidemic mouse model by feeding high-fat diet,SD mice fed Pu-erh tea at the dosages of 0.5,1.0 g/（kg·d） and 2.0 g/（kg·d） for 35 consecutive days.The total cholesterol（TCHO）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C） and low-density lipoprotein cholesterol（LDL-C） in the blood of SD mice were determined.Meanwhile,plasma thromboxane-B2（TXB2） and 6-keto-prostaglandin F1α（6-keto-PGF1α） were also analyzed by ELISA.The results showed that the levels of TCHO,TC,LDL-C and TXB2 in SD mouse blood exhibited a significant reduction in treatment groups while HDL-C and 6-keto-PGF1α revealed a significant increase（P〈0.05;P〈0.01） when compared with the control group.%采用高脂饲料饲喂法建立高脂血症大鼠模型,同时以0.5、1.0、2.0g/（kg.d）3种普洱茶的剂量饲喂昆明种SPF级雌性大鼠35d后,检测大鼠血液总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）的含量,采用ELISA法定量测定大鼠血浆血栓素B2（thromboxaneB2,TXB2）、6-酮前列腺素F1α（6-keto-PGF1α）的含量。结果表明,普洱茶能明显降低模型大鼠血液TG、TC、LDL-C、TXB2含量,提高HDL-C、6-keto-PGF1α含量。