硒蛋白及其对巨噬细胞功能调节作用的研究进展

摘要

Selenium can exert its physiological functions in the form of selenoproteins in immune system. Macrophages play a pivotal role in immune regulation and bacterial defense. Recently, it has been found by using mice fed on selenium-rich diets, gene knockout mice and monoclonal antibody technology that selenoproteins have signifi cant impact on redox status, migration and infl ammatory responses of macrophages. In this article, we review recent research advances in the effects of selenoproteins on redox level, walk characteristics and inflammation in macrophages at the molecular level. This review suggests that selenoproteins may have complicated molecular modulation mechanisms and prospect medicinal benefi ts.%硒蛋白作为体内硒的主要存在形式，在免疫反应等许多方面发挥重要的生理功能，而巨噬细胞则在免疫调节与抗微生物感染等方面具有关键作用。近年来，通过硒饲喂实验、基因敲除、单克隆抗体等多种实验手段，发现硒蛋白对巨噬细胞功能具有重要的调节作用。本文总结近年来硒蛋白在分子水平上，对巨噬细胞胞内的氧化还原水平、游走特征以及炎症反应影响，显示出硒蛋白在免疫反应中的复杂分子调节机制及未来的药用前景。