树莓酮对高血脂症大鼠血脂及炎症因子的影响

摘要

Objective： to explore the effect of raspberry ketone （RK） on lipid metabolism and inflammatory factors in hyperlipidemic rats. Methods： forty SD rats （half male and half female） were randomly divided into 5 groups. The rats fed normal food were served as normal control group; the tats fed high-fat diets for 4 weeks were administered with RK at the doses of 20, 10 g/L and 5 g/L to create high, middle and low dose groups. The rats in each group were killed after the administration of RK for 8 week. The body weight, visceral index, and serum lipid parameters such as TC, TG, HDL-C and LDL-C, apolipoprotein including apoA-Ⅰ and apoB, C-reactive protein （hs-CRP）, TNF- α and IL-6 were determined. Results： RK could significantly reduce TC, TG and LDL-C levels in hyperlipidemic rats and increase HDL-C content. Meanwhile, serum apoA-Ⅰ level revealed a significant elevation while apoB revealed an obvious reduction. Moreover, RK could reduce the ratio between liver and body weight, and significantly reduce serum hs-CRP, TNF-α and IL-6 contents. Conclusion： RK not only has a role in regulating blood lipids but also can modulate low inflammation state in hyperlipidemlc rats.%目的：探讨树莓酮（RK）对高血脂症大鼠血脂及血清炎症因子水平的调控作用。方法：40只雌雄各半的SD大鼠随机分为5组：正常对照组喂养普通饲料，高脂模型组喂养高脂饲料，RK高、中、低剂量组分别在喂养高脂饲料4周后给予20、10g／L和5g／L的树莓酮灌胃剂量，2mL／d。8周末处死各组大鼠，测定各组大鼠体质量、脏器指数、血脂（TC、TG、HDL-C、LDL—C）、载脂蛋白（ApoA—Ⅰ、ApoB）、超敏C反应蛋白（hs-CRP）和肿瘤坏死因子α（TNF-α）、白细胞介素-6（IL-6）等指标。结果：RK能显著降低高血脂症大鼠TC、TG、LDL-C水平，升高HDL—C水平，同时血清ApoA—Ⅰ水平亦显著升高，而ApoB水平显著降低；RK能降低高血脂症大鼠肝脏质量与体质量的比值；并能显著降低血清hs-CRP、TNF—α和IL-6等炎症因子水平。结论：RK具有调节高血脂症大鼠血脂的作用，并能改善高血脂症低度炎症状态。