枸杞多糖对2型糖尿病病人的短期干预

摘要

Objective： To study the effect of Lycium barbarum polysaccbaride （LBP） on hypoglycemic activity and cytokine in type 2 diabetic patients. Methods： The 1：1 matching method was used to select subjects according to their age （difference no more than 5 years old）, duration of diabetes （difference no more than 5 years） and drug type and doses. LBP or placebo was provided by 300 mg/d for 3 consecutive months. Results： Fasting serum glucose and TNF- α had a significant difference between two groups after administration for 3 months. However, no significant difference was observed in leptin, interleukin 6 （IL-6）, adiponectin and C reactive protein. Conclusion： LBP has the functions of decreasing serum glucose and reducing TNF- α in type 2 diabetic patients.%目的：研究枸杞多糖（LBP）对2型糖尿病人血糖及其胰岛素抵抗相关细胞因子的作用。方法：采用1：1匹配法选取年龄相差不超过5岁，糖尿病病程相差不超过5年，服药类型和剂量相近的糖尿病患者，分别服用LBP胶囊（300mg／d，持续3个月）和安慰剂进行干预和统计分析。结果：干预前后两组人群的血糖、肿瘤坏死因子仅（TNF—α）变化有统计学差异。两组的瘦素、白细胞介素-6（IL-6）、脂联素和C反应蛋白变化无统计学差异。结论：LBP能够通过抑制TNF-α水平缓解2型糖尿病患者的胰岛素抵抗，从而降低血糖。