富GABA米糠改善大鼠氧化应激和肝功能损伤

摘要

High-fat diet induced oxidative stress and liver function injury in rats were effectively improved through investigating GABA-enrich rice bran. The natural rice bran was transformed into the GABA-enrich rice bran by virtue of aminobutyric acid enzyme, which was acquired by adding GABA precursor substance L-Glu-tamic acid into it. It was clearly found that the content of GABA increased from 32 mg/100 g to 242 mg/100 g. Firstly, the natural rice bran and GABA-enrich rice bran were added into the high fat feedstuff respectively. Then, the effects of GABA-enrich rice bran on high-fat diet rats weight, liver function and even oxidative stress were studied, the experimental rats were divided into four categories - normal control group, high-fat feed group, natural rice bran, and GABA-enrich rice bran group. Finally, it was revealed that the rat weight in GA-BA-enrich rice bran group was lower than high fat fee group rats and natural rice bran group rats (P<0.5). Therefore, it was proved that the GABA-enrich rice was superior to the natural rice bran in reducing liver steatosis cells, aminotransferase, alkaline phosphatase and in improving liver oxidative stress.%研究富伽马氨基丁酸(γ-aminobutyric acid,GABA)米糠有效改善高脂饮食诱发大鼠氧化应激和肝功能损伤.添加GABA前体物L-谷氨酸,通过原米糠中脱酸酶转化获得富GABA米糠,其中GABA的含量由32 mg/100 g升高至242 mg/100 g.原米糠、富GABA米糠分别添加到高脂饲料,试验大鼠分为正常对照组、高脂饲料组、普通米糠组和富GABA米糠组,考察普通米糠、富GABA米糠对高脂饮食大鼠的体重、肝指数、肝功能及氧化应激的影响.富GABA米糠组大鼠体重明显低于高脂饲料组大鼠和普通米糠组大鼠(p<0.5),富GABA米糠在减轻肝脏细胞脂肪变性、降低转氨酶及碱性磷酸酶、改善肝脏氧化应激等方面优于普通米糠组大鼠.