Effect on production of Ganoderma lucidum in submerged culture by adding rice powder was studied, and the medium was optimized by central composite rotatable design （CCRD）. The specific rates Of the production on the two media were compared. The results showed that rice stalk powder with amount of 2.0% - 8.0% could induce synthesis of cellulase and can be used for growth and polysaccharide production of G. lucidum. The optimized concentration of glucose and rice stalk powder were 3.26% , 5. 771% by response surface methodology. The yields of biomass, extracellar-polysaccharide, Intracellar-polysaccharide and Cellulase reached （ 14.4 ± 0.8） U/mL, （383 ± 9） mg/L, （329±10）mg/g, （13.22 ±1）g/L respectively, which were 16. 1%,（22.3 ±0.1）%,（35.3±0.5）%, （38.9 ± 2） % higher than those on the medium before optimization. The specific growth rate （0.031 h ^-1 ） , specific production rate of EPS and IPS （ EPS ： 0.011 h^ - 1 . IPS ： 8.2 × 10 ^- 4 h ^- 1 ） was 44.6 % ,42.1% , 18 % lower than that by bean powder medium, while the specific production rate of eellulase （ 0. 062 h ^-1 ） was 44.1% higher. Although the production in rice stalk powder medium was lower than that in the bean powder medium, it has potential using rice stalk powder to produce high additional value products.%采用单因素试验研究了添加稻秆粉对灵芝生长、纤维素酶活性、多糖合成的影响，并用旋转中心组合设计对稻秆粉和葡萄糖的浓度进行了优化，同时比较了两种培养基中灵芝产品的比生成速率。结果表明：稻秆粉可以作为灵芝生长、纤维素酶和多糖合成的培养基质，添加量为2％～8．0％；经过响应面法分析后葡萄糖、稻秆粉最佳浓度分别为3．26％、5．771％。此条件下灵芝的最大生长量为（13．12±1）g／L，胞内多糖产量为（329±10）mg／g，胞外多糖产量为（383±9）mg／L，纤维素酶活性为（14．4±0．8）U／mL，分别比优化前提高16．1％、（22．3±0．1）％、（35．3±0．5）％、（38．9±2）％。同时灵芝的比生长速率0．031h^-1，胞外和胞内多糖的比生成速率分别为0．011h^-1、8．2×10^-4h^-1，分别比豆饼粉培养基中的低44．6％、42．1％、18％，而纤维素酶的比生成速率（0．062h^-1）比豆饼粉培养基中（0．043h^-1）的提高44．1％。尽管灵芝比生长速率及多糖比生成速率比豆饼粉的低，但从经济成本来看和资源利用来看，用稻秆粉为灵芝液体发酵基质生产多糖等高附加值产品是可行的。
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