α－硫辛酸联合甲钴胺治疗化疗药引起周围神经病变的疗效观察

摘要

目的：观察硫辛酸联合甲钴胺治疗化疗药所致周围神经病变的疗效。方法：将126例恶性肿瘤化疗后周围神经病变患者随机分为治疗组和对照组，每组63例。治疗组给予α－硫辛酸600 mg静脉滴注、1日1次，甲钴胺500μg，静脉注射、1日1次；对照组单用甲钴胺500μg，静脉注射、1日1次，疗程均为2周。比较2组患者治疗前后临床疗效。结果：治疗组患者总有效率为80．95％（51／63），对照组为47．62％（30／63），治疗组优于对照组，差异有统计学意义（P＜0．05）。结论：α－硫辛酸联合甲钴胺治疗化疗药引起周围神经病变安全、有效。%OBJECTIVE:To evaluate the clinical efficacy of α-lipoic acid plus mecobalamin for peripheral neuropathy induced by chemotherapy.METHODS:One hundred and tweenty six patients with chemotherapy-induced peripheral neuropathy were randomly divided into two groups ( of 63 cases each) to be treated with eitherα-lipoic acid (600 mg) q.d by intravenous infusion plus mecobalamin (500 μg) q.d by intravenous injection ( treatment groups) or with mecobalamin (500μg) q.d by intravenous infusion ( control group) for 2 weeks, the clinical efficacy between the two groups were compared.RESULTS: The response rate in the treatment group was better than in the control gorup [ 80.95%( 51/63 ) vs.47.62%( 30/63 ) , P <0.05 ] . CONCLUSIONS: α-Lipoic acid combined with mecobalamin are safe and effective in the treatment of peripheral neuropathy induced by chemotherapy.