盐酸米诺环素与莫匹罗星软膏联合治疗聚合性痤疮的疗效观察

摘要

OBJECTIVE:To probe into the clinical effects and safety of minocycline hydrochloride combined with mupirocin ointment in treatment of acne conglobata .METHODS:90 patients with acne conglobata admitted into the First Affiliated Hospital of Zhengzhou University from Oct .2014 to Oct .2015 were selected to be divided into the treatment group, control group one and control group two via the random number table , with 30 cases in each.The treatment group were treated with minocycline hydrochloride combined with mupirocin ointment , while the control group one were given single hydrochloride minocycline , and the control group two only received mupirocin ointment .The treatment course was 6 weeks.After treatment of 2, 4 and 6 weeks, the efficacy and adverse drug reactions of two groups were observed;blood and urine routine, liver and kidney function of two groups were observed before and after treatment .RESULTS:After treatment, the total effective rate of treatment group was 96.67% ( 29/30 ) , significantly higher than those of control group one [83.33%(25/30)] and control group two [80.00%(24/30)], with statistically significant difference (P <0.05). CONCLUSIONS: The efficacy of minocycline hydrochloride combined with mupirocin ointment in treatment of acne conglobata is significant , better than those of single hydrochloride minocycline and mupirocin ointment .%目的：探讨盐酸米诺环素与莫匹罗星软膏联合治疗聚合性痤疮的临床效果及安全性。方法：选取2014年10月—2015年10月郑州大学第一附属医院皮肤科收治的聚合性痤疮患者90例作为研究对象。以随机数字表法分为治疗组、对照1组、对照2组，每组各30例。治疗组患者给予盐酸米诺环素＋莫匹罗星软膏治疗，对照1组患者单用盐酸米诺环素治疗，对照2组患者单用莫匹罗星软膏治疗。3组患者的疗程均为6周，分别在治疗2、4、6周末观察疗效和不良反应，并在治疗前后检查血、尿常规和肝、肾功能。结果：治疗后，治疗组患者总有效率为96.67％（29／30），显著高于对照1组的83.33％（25／30）和对照2组的80.00％（24／30），差异均有统计学意义（P＜0.05）。结论：盐酸米诺环素与莫匹罗星软膏联合治疗聚合性痤疮，疗效确切，优于单用盐酸米诺环素或单用莫匹罗星软膏。