万古霉素鞘内注射联合腰大池持续外引流治疗颅内感染的疗效观察

摘要

OBJECTIVE:To probe into the clinical effects of vancomycin intrathecal injection combined with external drainage of lumbar cistern in treatment of intracranial infection .METHODS:108 patients with intracranial infection admitted into Yongcheng People ’s Hospital from Oct.2013 to Dec.2014 were selected to be divided into observation group and control group via the random number table , with 54 cases in each.The control group were treated with vancomycin intrathecal injection alone , while the observation group received vancomycin intrathecal injection combined with external drainage of lumbar cistern .The clinical effects and infection control of two groups were observed .RESULTS: After treatment , the total effective rate of observation group was 98.15%( 53/54 ) , significantly higher than that of control group 75.93%(41/54), with statistical significance (P<0.05).Meanwhile, the intracranial pressure of observation group was ( 120.54 ±19.11 ) mmHg ( 1 mmHg =0.133 kPa ) , significantly lower than that of control group [ ( 176.38 ±23.75 ) mmHg ] , with statistical significance ( P<0.05 ) .Compare the two groups after treatment in patients with cerebrospinal fluid white blood cell count , protein content and glucose content in the aspect ( P<0.05) .CONCLUSIONS:The clinical effects of vancomycin intrathecal injection combined with external drainage of lumbar cistern on patients with intracranial infection are significant , which can improve the clinical efficacy and symptoms of intracranial infection , lower the intracranial pressure and improve the living quality of patients .It is worthy of application and promotion .%目的：探讨万古霉素鞘内注射联合腰大池持续外引流治疗颅内感染的临床效果。方法：选取2013年10月—2014年12月永城市人民医院收治的颅内感染患者108例作为研究对象，以随机数字表法分为观察组和对照组各54例。对照组患者单独采用万古霉素鞘内注射，观察组采用万古霉素鞘内注射联合腰大池持续外引流。观察2组患者的治疗效果及感染控制情况。结果：治疗后，观察组患者的总有效率为98．15％（53／54），明显高于对照组的75．93％（41／54），差异有统计学意义（P＜0．05）；观察组患者的颅内压为（120．54±19．11） mmHg（1 mmHg＝0．133 kPa），明显低于对照组的（176．38±23．75） mmHg，差异有统计学意义（P＜0．05）；2组患者治疗后的脑脊液中白细胞计数、蛋白质含量、葡萄糖含量比较，差异均有统计学意义（ P＜0．05）。结论：颅内感染的患者采用万古霉素鞘内注射联合腰大池持续外引流治疗效果明显，能提高疗效，改善颅内感染症状，降低颅内压，改善患者生活质量，可推广应用。