替吉奥同步放疗序贯化疗治疗胃癌根治术后腹腔淋巴结转移瘤的疗效与安全性

摘要

目的:探讨替吉奥同步放疗序贯化疗治疗胃癌根治术后腹腔淋巴结转移瘤的疗效与安全性.方法:选取2013年7月-2016年3月洛阳市中心医院收治的行胃癌根治术后腹腔淋巴结转移瘤患者86例作为研究对象,以随机数字表法分为观察组和对照组,每组43例.两组患者均给予放疗,观察组患者于放疗第1日给予替吉奥胶囊.对比观察两组患者的临床疗效及控制情况、不良反应发生情况.结果:观察组患者的总有效率、临床控制率分别为60.5％(26/43)、96.3％ (41/43),明显高于对照组的34.9％ (15/43)、86.0％(37/43),差异均有统计学意义(P＜0.05).两组患者肝肾损伤、血小板减少症、白细胞减少症发生率的差异无统计学意义(P＞0.05);观察组患者贫血、消化道反应发生率分别为14.0％ (6/43)、20.9％(9/43),明显高于对照组的4.7％(2/43)、9.3％ (4/43),差异均有统计学意义(P＜0.05).结论:替吉奥同步放疗序贯化疗治疗胃癌根治术后腹腔淋巴结转移瘤的疗效显著,但患者贫血和消化道反应较多.%OBJECTIVE:To probe into the efficacy and safety of Tegafur gimeracil oteracil potassium capsule combined with radiation sequential chemotherapy in treatment of abdominal lymph node metastases after gastrectomy.METHODS:86 patients with abdominal lymph node metastases after gastrectomy admitted into Luoyang Central Hospital from Jul.2013 to Mar.2016 were extracted to be divided into observation group and control group via the random number table,with 43 cases in each.Two groups were given radiotherapy,and the observation group were given Tegafur gimeracil oteracil potassium capsule on the 1 st day of radiotherapy.The clinical efficacy and control conditions of two groups were observed,differences of incidence of adverse drug reactions were compared between two groups.RESULTS:The total effective rate and clinical control rate of observation group were respectively 60.5％ (26/ 43)and 96.3 ％ (41/43),significantly higher than those of control group [34.9％ (15/43),86.0％ (37/43)],with statistically significant difference (P ＜ 0.05).There was no statistically significant difference between two groups in the differences of incidence of liver renal toxicity,thrombocytopenia and leukopenia (P ＞ 0.05).The incidences of anemia,gastrointestinal reactions of observation groups were respectively 14.0％ (6/43)and 20.9％ (9/43),significantly higher than those of control group [4.7 ％ (2/43),9.3 ％ (4/43)],with statistically significant difference (P ＜ 0.05).CONCLUSIONS:The efficacy of Tegafur gimeracil oteracil potassium capsule combined with radiation sequential chemotherapy in treatment of abdominal lymph node metastases after gastrectomy is significant,yet the incidences of anemia,gastrointestinal reactions are relatively high.